神龙大侠阿宝（杰克·布莱克 Jack Black 配音）再度归来，要被师父（达斯汀·霍夫曼 Dustin Hoffman 配音）强行进阶修行。系列全新最强反派魅影妖后（维奥拉·戴维斯 Viola Davis 配音）登场，神秘莫测的她可以幻化成每一个阿宝的昔日宿敌。此次阿宝又结识了小真（奥卡菲娜 Awkwafina 配音）等新伙伴，并将一同开启这场冒险旅程。
Searching for an adventurous story in the woods, a group of journalism students awaken a superhuman being from its lost cryo-chamber. A long night of man hunting and desperation ensues.
Best friends Karl and Miles stumble upon a remote cabin, believing it's their chance to strike it rich. However, their plans are thwarted by the looming apocalypse, creating a comedic and horrific predicament for the duo.
