Joey begins her first day at Worthington University where she is struggling in her beginners writing class taught by Professor David Wilder who criticizes her first essay about her and Dawson. Audrey Liddell, Joey's brash new roommate from Beverly Hills, proves to be more of an annoyance than a friend with her wild and crazy personality. Dawson, who's continuing his studies at USC with an internship in Hollywood, begins his job on a shaky start when he meets Todd Carr, an arrogant, egocentric, hack film director who gives Dawson a hard time. Meanwhile, Jen pays Pacey a visit, who's lying low as he docks his yacht in Boston Harbor after sailing away the summer. At nearby Boston Bay College, Jen and Jack are invited to their first fraternity party. They persuade Joey to come along with Audrey who seems to get along with Jen and Jack, much to Joey's surprise. Also, Jen meets Charlie, a bass player. She is rude to him, insulting him away, but deep inside feels strongly attracted to him.
After being wheelchair-bound from a crash, María José "Santita" Cano left her love at the altar. 20 years later, his return makes her face her past choices and test the limits of her love.
After attending a medical conference in Beijing and coming frighteningly close to dying in a car crash, Dr Matthew Nolan, played by Armitage (Obsession, Stay Close) arrives home and is immediately arrested at London’s Heathrow Airport. Exhausted and confu